Possible interplay between interleukin-15 and interleukin-17 into the pathogenesis of idiopathic inflammatory myopathies
نویسندگان
چکیده
منابع مشابه
The role of interleukin-17 in immune-mediated inflammatory myopathies and possible therapeutic implications.
The idiopathic inflammatory myopathies are a heterogeneous group of autoimmune muscle disorders with distinct clinical and pathological features and underlying immunopathogenic mechanisms. Traditionally, CD4(+) Th1 cells or CD8(+) cytotoxic effector T cells and type I/II interferons have been primarily implicated in the pathogenesis of the inflammatory myopathies. The presence of IL-17A produci...
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The idiopathic inflammatory myopathies (IIM): polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM) are chronic rheumatic muscle diseases of unknown origin that are characterized by muscle weakness and by inflammatory infiltrates in the skeletal muscle. Treatment with glucocorticoids and other immunosuppressive agents has improved outcome but not all patients respond to this...
متن کاملRole of interleukin 15 and interleukin 18 in inflammatory response.
Interleukin 15 (IL15) and interleukin 18 (IL18) are cytokines produced principally by macrophages during innate immune response and subsequently profoundly influence adaptive immunity. Recent studies have shown that IL15 and IL18 play an influential part in inflammatory response. Here we present recent data mainly from our own laboratories illustrating the importance of IL15 and IL18 in the ind...
متن کاملImmune mechanisms in the pathogenesis of idiopathic inflammatory myopathies
Idiopathic inflammatory myopathies (IIMs), comprising polymyositis, dermatomyositis, and inclusion-body myositis, are characterized by inflammatory cell infiltrates in skeletal muscle tissue, muscle weakness, and muscle fatigue. The cellular infiltrates often consist of T lymphocytes and macrophages but also, in some cases, B lymphocytes. Emerging data have led to improved phenotypic characteri...
متن کاملTargeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases
Interleukin (IL)-15 is a dangerous inflammatory cytokine that induces tumor-necrosis factor-alpha, IL-1beta and inflammatory chemokines. It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell death and facilitates maintenance of CD8+ memory T-cell survival including that of self-directed memory cells. Disordered IL-15 expression has been reported in patients with an array ...
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ژورنال
عنوان ژورنال: Reumatismo
سال: 2014
ISSN: 2240-2683,0048-7449
DOI: 10.4081/reumatismo.2014.746